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Looe Key locate via mapquest Description Looe Key is part of Florida Keys National Marine Sanctuary, and you can only get there by boat. Divers like it for its coral formations. You’ll find five square miles of perfect snorkeling. Several wrecked ships also lie within the sanctuary, including the 1744 British frigate HMS Looe. Yellow buoys mark where marine life is protected. Headquarters at 216 Ann Street, Key West. Address 6.7 nautical miles southeast of Big Pine Key Big Pine, FL